 | 主任(PI): 顾连峰 （Lianfeng Gu, PhD） |
团队成员(Members)：张航晓（Hangxiao Zhang,PhD）,刘旭庆（Xuqing Liu,PhD）,张泽宇（Zeyu Zhang）,赵良真（Liangzhen Zhao）,徐惠昌（Huichang Xu）,张珺（Jun Zhang）,靳晓霞（Xiaoxia Jin）,杨珺（Jun Yang）,赵梦娜（Mengna Zhao）,楼衎睿（Kanrui Lou）,向圣才（Shengcai Xiang）,郭弘钰（Hongyu Guo）,陈剑龙（Jianlong Chen）,王紫萱（Zixuan Wang）,王雨森（Yusen Wang）,王铭哲（Mingzhe Wang）,王如雪（Ruxue Wang）,严英洁（Yingjie Yan）,杨思雨（Siyu Yang）,华天（Tian Hua）,唐美璇（Meixuan Tang）,
PI简介(PI Introduction)：
顾连峰现为林学中心全职教授，博士生导师。2012年获得中国科学院生物信息学博士学位，2015年从美国加州大学河滨分校回国，入选福建省引进高层次人才和闽江学者特聘教授，第十四届林业青年科技奖和梁希林业科技进步奖获得者。先后主持多项林学基金项目，包括国家自然基金面上项目三项、重点研发子课题三项。共发表六十多篇SCI论文。在林学相关领域有多篇通讯作者SCI论文，在Genome Biology、Plant Physiology、 Plant Journal、Bioinformatics和Journal of Integrative Plant Biology等期刊发表。
实验室网址：https://teacher.fafu.edu.cn/glf1/
电子邮箱：lfgu@fafu.edu.cn
研究领域 （Research focus）:
林木表观遗传学和生物信息学。长期从事林木表观遗传学相关研究，以毛竹、杉木、杨树及木麻黄为研究对象，结合多组学数据和分子生物学等手段，解析表观遗传对林木生长发育胁迫应答调控。
Forest Tree Epigenetics and Bioinformatics. Long-term research in forest tree epigenetics, focusing on Moso bamboo, Chinese fir, poplar, and casuarina as model species. Integrates multi-omics data and molecular biology approaches to elucidate the role of epigenetics in regulating growth, development, and stress responses in forest trees.
发表文章(Publications):
2026
Zhang Z,Lin W,Yang D,Tian H,Yan Y,Zhang J,Wang H,et al.(2026) Epigenomic reprogramming underlies internodal developmental heterogeneity in rapidly elongating bamboo shoots. Plant Physiology.11:kiag131. doi: 10.1093/plphys/kiag131.
Xu H,You L,Yu J,Sen N,Zhang H,Ye G and Gu L.(2026) From resistance screening to biomarker discovery: the α-linolenic acid-phenylpropanoid pathway as defence indicator against Lymantria xylina in Casuarina equisetifolia. Tree Physiology. 46(3): tpag008. doi: 10.1093/treephys/tpag008.
Zhang Z,Ma Z,Tian H,Liu X,Xiang S and Gu L.(2026) OmicsCanvas: A multi-omics platform for integration and visualization of epigenetic regulation. Journal of Integrative Plant Biology. doi: 10.1111/jipb.70258.
2025
Wu L,Gu Y,Guo H,Zhang J,Yang J,Zhang M,Wang H,Zhao L,Zhang H,Gu L. (2025) BaMV-vectored compact AsCas12f1-HKRA enables transgene-free genome editing in Moso bamboo (Phyllostachys edulis). Plant Biotechnol J.doi: 10.1111/pbi.70474.
Li X,Wu L,Wang H,Zhang J,Jing X,Zhang Z,Wang Y,Wang H,Liu W,Wang R,Zhao L,Zhang H,Gu L. (2025) N6-methyladenosine and poly(A) tail-mediated posttranscriptional regulation in bamboo mosaic virus–Dendrocalamus latiflorus interactions. Plant J.124(5):e70604.doi: 10.1111/tpj.70604.
Wang H,Wang H,Jia Y,Jin X,Wu H,Yang S,Zhao L,Zhang H,Gu L. (2025) The RNA m6A Methyltransferase PheMTA1 and PheMTA2 of Moso Bamboo Regulate Root Development and Resistance to Salt Stress in Plant.Plant Cell Environ.48(7):5184-5197.
Wu L,Yang J,Gu Y,Wang Q,Zhang Z,Guo H,Zhao L,Zhang H,Gu L.(2025) Bamboo mosaic virus-mediated transgene-free genome editing in bamboo. New Phytol.245(5):1810-1816.
Wang H,Wang H,Jia Y,Li T,Yang S,Jin Y,Zhong Z,Bai W,Zheng H,Zhao L,Lin C,Reddy A,Zhang H,Gu L(2025) HyperTRIBE mapping of the RNA m6A demethylase ALKBH9 binding sites in bamboo reveals its role in plant defense. Plant Physiol. doi: 10.1093/plphys/kiaf457.
Liu Z,Fan X,Liu X,Zhang Z,Li X,Yan Y,Xiang S,Zhang X,Lu T,Lu S,Liu D,Hua T,Zhao M,Zhang H,Gu L.(2025) Overexpression of the ABA-responsive transcription factor PtrMYBH alters shoot apical meristem, xylem, root, and leaf development in Populus. The Plant Journal. 09 July 2025 https://doi.org/10.1111/tpj.70337.
Wang H,Wang H,Wu H,Lou K,Jin X,Tang M,Wang Z,Zhao L,Gu L,Zhang H.(2025) Transcriptome-Wide m6A Modification and Poly(A) Tail Length Changes in Moso Bamboo Induced by Gibberellin Revealed by Nanopore Direct RNA Sequencing. Industrial Crops & Products.225.
2024
Zhang C,Tang H,li T,Wu H,Gu Y,Zhang J,Zhang Z,Zhao L,Li Y,Gu L and Zhang H.(2024) Integrating Physiological Features and Proteomic Analyses Provides New Insights in Blue/Red Light-Treated Moso Bamboo (Phyllostachys edulis). Journal of Agricultural and Food Chemistry. 72(22):12859-12870.
2023
Xi F,Zhang Z,Wu L,Wang B,Gao P,Chen K,Zhao L,Gao J,Gu L Zhang H.(2023) Insight into gene expression associated with DNA methylation and small RNA in the rhizome-root system of Moso bamboo. International Journal of Biological Macromolecules. 248:125921.
Jin Y,Wang B,Bao M,Li Y,Xiao S,Wang Y,Zhang J,Zhao L,Zhang H,Hsu Y,Li M,Gu L. (2023) Development of an efficient expression system with large cargo capacity for interrogation of gene function in bamboo based on bamboo mosaic virus. J Integr Plant Biol.https://doi.org/10.1111/jipb.13468.
Wang Y,Wang H,Wang H,Zhou R,Wu J,Zhang Z,Jin Y,Li T,Kohnen M,Liu X,Wei W,Chen K,Gao Y,Ding J,Zhang H,Liu B,Lin C,Gu L. (2023) Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis). Genomics, Proteomics & Bioinformatics. https://doi.org/10.1016/j.gpb.2023.01.007.
Zhang Y,Wei Y,Meng J,Wang Y,Nie S,Zhang Z,Wang Y,Gao Y,Wu J,Li T,Liu X,Zhang H,Gu L. (2023) Chromosome-scale de novo genome assembly and annotation of three representative Casuarina species: C. equisetifolia, C. glauca, and C. cunninghamiana . Plant Journal. https://doi.org/10.1111/tpj.16201 .
Liao J,Deng B,Yang Q,Li Y,Zhang Y,Cong J,Wang X,Kohnen M,Liu Z,Lu M,Lin D,Gu L,Liu B.(2023) Insights into Cryptochrome Modulation of ABA Signaling to Mediate Dormancy Regulation in Marchantia polymorpha. New Phytol.238(4):1479-1497.
2022
Gao Y,Liu X,Jin Y,Wu J,Li S,Li Y,Chen B,Zhang Y,Wei L,Li W,Li R,Lin C,Reddy A,Jaiswal R,Gu L.(2022) Drought induces epitranscriptome and proteome changes in stem-differentiating xylem of Populus trichocarpa. Plant Physiology. https://doi.org/10.1093/plphys/kiac272.
Li T,Wang H,Zhang Y,Wang H,Zhang Z,Liu X,Zhang Z,Liu K,Yang D,Zhang H,Gu L.(2022) Comprehensive profiling of epigenetic modifications in fast-growing moso bamboo shoots. Plant Physiology. https://doi.org/10.1093/plphys/kiac525.
Zhang Z,Wang H,Wu J,Jin Y,Xiao S,Li T,Liu X,Zhang H,Zhang Z,Su J,Liu J,Wang X,Gao Y,Ma X and Gu L. (2022) Comprehensive Transcriptome Analysis of Stem-Differentiating Xylem Upon Compression Stress in Cunninghamia Lanceolata.Frontiers in Genetics. https://doi.org/10.3389/fgene.2022.843269.
Zheng Y,Yang D,Rong J,Chen L,Zhu Q,He T,Chen L,Ye J,Fan L,Gao Y,Zhang H,Gu L.(2022) Allele-aware chromosome-scale assembly of the allopolyploid genome of hexaploid Ma Bamboo (Dendrocalamus latiflorus Munro). Journal of Integrative Plant Biology. https://doi.org/10.1111/jipb.13217.
2021
Wang X, Jiang B, Gu L, Chen Y, Mora M, Zhu M, Noory E, Wang Q, Lin C.(2021) A photoregulatory mechanism of the circadian clock in Arabidopsis.Nature Plants.7(10):1397-1408.
Zhang Z, Wang H, Wang Y, Xi F, Wang H, Kohnen MV, Gao P, Wei W, Chen K, Liu X, Gao Y, Han X, Hu K, Zhang H, Zhu Q, Zheng Y, Liu B, Ahmad A, Hsu YH, Jacobsen SE, Gu L. (2021) Whole genome characterization of chronological age-associated changes in methylome and circular RNAs in moso bamboo (Phyllostachys edulis) from vegetative to floral growth. Plant J. doi: 10.1111/tpj.15174. Gao Y, Liu X, Wu B, Wang H, Xi F, Kohnen MV, Reddy ASN, Gu L. (2021) Quantitative profiling of N6-methyladenosine at single-base resolution in stem-differentiating xylem of Populus trichocarpa using Nanopore direct RNA sequencing. Genome Biol.22(1):22. doi: 10.1186/s13059-020-02241-7.
2020
Wang Y, Wang H, Xi F, Wang H, Han X, Wei W, Zhang H, Zhang Q, Zheng Y, Zhu Q, Kohnen MV, Reddy ASN, Gu L. (2020) Profiling of circular RNA N6 -methyladenosine in moso bamboo (Phyllostachys edulis) using nanopore-based direct RNA sequencing. J Integr Plant Biol. 62(12):1823-1838.
2018-2019
Gao Y, Xi F, Zhang H, Liu X, Wang H, Zhao L, Reddy A, Gu L.(2019) Single-molecule real-time (SMRT) isoform sequencing (Iso-Seq) in plants: The status of the bioinformatics tools to unravel the transcriptome complexityCurrent Bioinformatics （14）:566-573.
Wang Q, Zuo Z, Wang X, Liu Q, Gu L, Oka Y, Lin C.(2018) Beyond the photocycle – how cryptochromes regulate photoresponses in plants?Current Option in Plant Biology45:120-126.
Zhang H, Wang H, Zhu Q, Gao Y, Wang H, Zhao L, Wang Y, Xi F, Wang W, Yang Y, Lin C, Gu L.(2018) Transcriptome characterization of moso bamboo (Phyllostachys edulis) seedlings in response to exogenous gibberellin applicationsBMC plant biology18(1):125. doi: 10.1186/s12870-018-1336-z.
2017
Taotao Wang , Huiyuan Wang, Dawei Cai, Yubang Gao, Hangxiao Zhang,Yongsheng Wang , Chentao Lin , Liuyin Ma , Lianfeng Gu .(2017) Comprehensive profiling of rhizome-associated alternative splicing and alternative polyadenylation in moso bamboo (Phyllostachys edulis) The Plant Journal doi: 10.1111/tpj.13597.
2016
Wang Q,Zuo Z C,Wang X,Gu L F, Yoshizumi T,Yang,Z H,Liu Q,Liu W,Han Y J,Liu B, Wohlschlegel J A, Matsui M, Oka Y and Lin C.(2016) Photoactivation and inactivation mechanisms of Arabidopsis cryptochrome2 Science354:343-347.
Li C, Gu L, Gao L, Chen C, Wei C, Qiu Q, Chien C, Wang S, Jiang L, Chen C, Yang S, Nguyen V, Snyder M, Burlingame A, Kohalmi S, Huang S, Cao X, Wang Z, Wu K, Chen X, Cui Y. (2016) Concerted genomic targeting of histone H3 lysine 27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis Nature genetics48(6):687-693.
Wu, Z, Zhu D, Lin X, Miao L, Gu L, Deng X, Yang Q, Sun K, Zhu D, Cao X, TSUGE T, Dean C, Aoyama T, Gu H, Qu L. (2016) RNA-binding proteins At RZ-1B and At RZ-1C play a critical role in regulation of pre-mRNA splicing and gene expression during Arabidopsis development The Plant Cell28(1):55-73.
Yan H, Zhang H, Wang Q, Jian H, Qiu X, Baudino S, Just J, Raymond O, Gu L, Jihua W, Bendahmane M and Tang K. (2016) The Rosa chinensis cv. Viridiflora phyllody phenotype is associated with misexpression of flower organ identity genes Front Plant Sci (12)7:996. doi: 10.3389/fpls.
Li S, Zhang G, Zhang X, Yuan J, Deng C, Gu L, Gao W.( 2016) DPTEdb, an integrative database of transposable elements in dioecious plants Database 5(12) baw078 doi:10.1093/database/baw078.
Cui X, Lu F, Qiu Q, Zhou B, Gu L, Zhang S, Kang Y, Cui X, Ma X, Yao Q, Ma J, Zhang X, Cao X. (2016) REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis Nature genetics48(6):694-699.
Deng X, Lu T, Wang L, Gu L, Sun J, Kong X, Liu C, Cao X. (2016) Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5 PNAS 113(19):5447-5452.
Zhang S, Xu M, Qiu Z, Wang K, Du Y, Gu L, Cui X.(2016) Spatiotemporal transcriptome provides insights into early fruit development of Solanum lycopersicum Sci Rep18;6, 23173; doi: 10.1038/srep23173.
2015
Zhang Y, Gu, L, Hou, Y, Wang L, Deng, X, Hang, R, Chen, D, Zhang, X, Zhang, Y, Liu, C, and Cao, X. (2015) Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein， regulates plant flowering by targeted alternative polyadenylation Cell Research25(7):864-876.
2014
Zhou H, Zhou M, Yang Y, Li J, Zhu L, Jiang D, Dong J, Liu Q, Gu L, Zhou L., Cao X, Zhuang C. (2014) RNAase Zs1 processes UBL40 mRNA and controls thermo-sensitive genic male sterility in rice NATURE COMMUNICATIONSdoi:10.1038/ncomms5884.
Wei L, Gu L, Song X, Cui X, Lu Z, Zhou M, Wang L, Hu F, Zhai J, Meyer B, Cao X. (2014) Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice Proc Natl Acad Sci U S A111: 3877-3882.
Wu B, Suo F, Lei, W and Gu, L.(2014) Comprehensive Analysis of Alternative Splicing in Digitalis purpurea by Strand-Specific RNA-Seq PLoS One9, e106001.
Before 2014
Cui X, Jin P., Cui X, Gu L, Lu Z, Xue Y, Wei L, Qi J, Song X, Luo M, Gynheung An, Cao X. (2013) Control of Transposon Activity by a Histone H3K4 Demethylase in Rice Proc Natl Acad Sci U S A110(5):1953-1958.
Wang L, Song X, Gu L, Li X, Cao S, Chu C, Cui X, Chen X, and Cao X. (2013) NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis Plant Cell25: 715-727.
Zhang L, Cheng Z, Qin R, Qiu Y, Wang J, Cui X, Gu L, Zhang X, Guo X, Wang D, Jiang L, Wu C, Wang H, Cao X, Wan J. (2012) Identification and Characterization of an Epi-1 allele of OsFIE1 Reveals a Regulatory Linkage between two Epigenetic Marks in Rice Plant Cell24: 4407-4421.
Deng X, Gu L, Liu C, Lu T, Lu F, Lu Z, Cui P, Pei Y, Wang B, Hu S, and Cao X. (2010) Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing Proc Natl Acad Sci U S A 107: 19114-19119.
Zhou M, Gu L, Li P, Song X, Wei L, Chen Z. and Cao X. (2010) Degradome sequencing reveals endogenous small RNA targets in rice (Oryza sativa L. ssp. indica) Front. Biol5: 67–90.
Gu,L and Guo,R.(2007) Genome-wide detection and analysis of alternative splicing for nucleotide binding site-leucine-rich repeats sequences in rice J Genet Genomics34: 247-257.