 | 主任(PI): 刘圆圆 (Yuanyuan Liu, PhD) |
团队成员 (Members): 何庆峰(Qingfeng He),蔡森（Sen Cai）,沈铭伟(Mingwei Shen),黎帅（Shuai Li）,林成伟（Chengwei Lin）,林静(Jing Lin),段炜鑫(Weixin Duan),宋雨欣（Yuxin Song）,吴昊炜（Haowei Wu）,杨雨露（Yulu Yang）,吴大子（Dazi Wu）,吕晨雨(Chenyu Lv),严舒琪（Shuqi Yan）,林泽盛（Zesheng Lin),赵昱诚(Yucheng Zhao),蒲根（Gen Pu）,黄唯一（Weiyi Huang）,窦海艺（Haiyi Dou）,蒋思涵（Sihan Jiang）,陈筠泉（Yunquan Chen）,林鑫鑫（Xinxin Lin）,王紫宁（Zining Wang）,余芷瑶（Zhiyao Yu）,刘慧娴（Huixian Liu）
PI简介 (PI Introduction)：
刘圆圆，福建省“闽江学者”特聘教授，入选国家高端外国专家引进计划，福建省高层次人才(B类)等国家级和省部级人才计划项目。 2015年，获得加拿大不列颠哥伦比亚大学（University of British Columbia，UBC）博士学位，于同年获得Mitacs博士后专项资助。2015-2018年在加拿大不列颠哥伦比亚大学及Anandia科技公司（Anandia Laboratories Inc.）担任研发科学家及博士后研究员。
研究领域 (Research focus):
发现并工程化植物代谢途径，以产生能够改善人类和植物健康的化学物质和分子。我们团队专注于开发植物中高价值的专性代谢物的生物合成途径相关的基本理论及合成所需的工具。
My research interests lie in the discovery and engineering of plant metabolic pathways to produce chemical and molecules that can improve human and plant health. Our lab focuses on developing the foundational knowledge and innovation tools needed for engineering biosynthetic pathways for high-value specialized metabolites in planta.
发表文章 (Publications):
2025
Li M,Ouyang Y,Cai S,Zhang Z,Wu Q,Li S,Huang X,Huang S,Ao D,You S,Cai J,Vasseur L,Lin C,Liu Y.(2025) A New UV-B Protectant in Plant: Insights Into THCAS and THCA's Role in UV-B Tolerance. Plant Cell Environ. 48(10):7729-7742.
2024
Li T, Guo J, Hu G, Yu X, Cao F, Su H, You M, Liu Y, Gurr G, You S. (2024) Zinc finger proteins facilitate adaptation of a global insect pest to climate change. BMC Biology. (accepted)
Chen X, Yao S, Xie L, Li J, Xiong L, Yang X, Chen Y, Cao F, Hou Q, Liu Y, Gurr G, You S. (2024) Disruption of the odorant receptor co-receptor (Orco) reveals its critical role in multiple olfactory behaviors of a cosmopolitan pest. Insect Biochemistry and Molecular Biology. DOI: 10.1016/j.ibmb.2024.104248.
Liu Y, Li S, She M, Guo F, Li M, Sen C, Huang J, Wu J, Li X, Peng L, Huang M, Ao D, Zhu X, You S, Liu Y. (2024) Integration of transcriptome and metabolome provides insights into metabolites and pathways associated with antiproliferative activity of cannabis flower extracts. Industrial Crops and Products. DOI: 10.1016/j.indcrop.2024.120239.
Song X, Ohbayashi I, Song S, Wang Q, Yang Y, Lu M, Liu Y, Sawa S, Furutani M. (2024) TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots. Frontiers in Plant Science. DOI: 10.3389/fpls.2024.1462235.
Li M, Wu Q, Guo F, Ouyang Y, Ao D, You S, Liu Y. (2024) A versatile, rapid agrobacterium-mediated transient expression system for functional genomics studies in cannabis seedling. Planta. DOI:10.1007/s00425-024-04448-5
You S, Yao S, Chen X, Hou Q, Liu Z, Lei G, Xie X, Liang Z, Yuchi Z , You M, Liu Y, Xiong L. (2024). CRISPR/Cas9-Mediated Knockout of the PxJHBP Gene Resulted in Increased Susceptibility to Bt Cry1Ac Protoxin and Reduced Lifespan and Spawning Rates in Plutella xylostella. Journal of Agricultural and Food Chemistry. DOI: 10.1021/acs.jafc.3c08721.
Huang X, Chen W, Zhao Y, Chen J, Ouyang Y, Li M, Gu Y, Wu Q, Cai S, Guo F, Ao D, Zhu P, You S, Vasseur L, Liu Y. (2024) Deep learning-based quantification and transcriptomic profiling reveal a methyl jasmonate‐mediated glandular trichome formation pathway in Cannabis sativa. The Plant Journal. DOI: 10.1111/tpj.16663.
2023
Li Z, Xiong L, Li J, Yao S, Dong Y, Li Y, Chen X, Ye M, Zhang Y, Xie X, You M, Yuchi Z, Liu Y, You S. (2023) Enhanced resistance to Bacillus thuringiensis Cry1Ac toxin mediated by the activation of prophenoloxidase in a cosmopolitan pest. International Journal of Biological Macromolecules. DOI: 10.1016/j.ijbiomac.2023.124678.
2022
Ma J, Li Q, Zhang L, Cai S, Liu Y, Lin J, Huang R, Yu Y, Wen M, Xu, T. (2022) High auxin stimulates callus through SDG8-mediated histone H3K36 methylation in Arabidopsis. Journal of Integrative Plant Biology. DOI:10.1111/jipb.13387.
Zhu P, Zhao Y, You X, Zhang Y, Vasseur L, Haughn G, Liu Y. (2022) A versatile protoplast system and its application in Cannabis sativa L. Botany. DOI:10.1139/cjb-2021-0178.
2021
Liu Y, Zhu P, Cai S, Haughn G, Page JE. (2021) Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L.Plant Mol Biol. doi: 10.1007/s11103-021-01129-9.
Cai S, Zhang Z, Huang S, Bai X, Huang Z, Zhang YJ, Huang L, Tang W, Haughn G, You S, Liu Y. (2021) CannabisGDB: a comprehensive genomic database for Cannabis Sativa L. Plant Biotechnol J. doi: 10.1111/pbi.13548.
2019
Liu ,Y., Wu, C., Hu ,X., Gao, H., Wang, Y., Luo, H., Sen ,C., Li, G., Zheng, Y., Lin ,C., Zhu, Q.(2019) Transcriptome profiling reveals the crucial biological pathways involved in cold response in Moso bamboo (Phyllostachys edulis) Tree Physiology DOI:10.1093/treephys/tpz133.
2016
Li ,W., Liu, Y., Douglas, C.(2016) Role of glycosyl transferases in pollen wall primexine formation and exine patterning Plant Physiology DOI:10.1104/pp.16.00471.
Before 2016
Liu,Y., You,S., Taylor-Teeples,M., Brady ,S., Li,L., Schuetz ,M., Douglas,C. (2014) BEL1-LIKE HOMEODOMAIN6 (BLH6) and KNOTTED ARABIDOPSIS THALIANA7 (KNAT7) interact and regulate secondary cell wall formation via repression of REVOLUTA Plant Cell DOI:10.1105/tpc.114.128322.
You ,M., Yue, Z., He, W., Yang ,X., Yang, G., Xie, M., Zhan, D., Baxter,S., Vasseur,L., Gurr ,G., Douglas,C., Bai ,J., Wang ,P., Cui ,K., Huang, S., Li ,X., Zhou ,Q.et al. (2013) A heterozygous moth genome provides insights into herbivory and detoxification Nature Genetics DOI:10.1038/ng.2524.
Khan, M., Xu, M., Murmu, J., Tabb ,P., Liu ,Y., Storey ,K., McKim ,S., Douglas,C., Hepworth, S.(2011) Antagonistic interaction of BLADE-ON-PETIOLE1 and 2 with BREVIPEDICELLUS and PENNYWISE regulates Arabidopsis inflorescence architecture Plant Physiology DOI:10.1104/pp.111.188573.
Li ,E., Wang, S., Liu, Y., Chen, J., Douglas ,C.(2011) OVATE FAMILY PROTEIN4 (OFP4) interacts with KNAT7 in a transcription repression complex to regulate secondary cell wall formation in Arabidopsis thaliana Plant Journal DOI:10.1111/j.1365-313X.2011.04595.x.